我们介绍了一个简单而直观的自我实施任务，自然合成异常（NSA），用于训练仅使用正常培训数据的端到端模型，以实现异常检测和定位。NSA将Poisson图像编辑整合到来自单独图像的各种尺寸的无缝混合缩放贴片。这会产生广泛的合成异常，与以前的自我监督异常检测的数据 - 启发策略相比，它们更像自然的子图像不规则。我们使用天然和医学图像评估提出的方法。我们对MVTEC AD数据集进行的实验表明，经过训练的用于本地NSA异常的模型可以很好地概括地检测现实世界中的先验未知类型的制造缺陷。我们的方法实现了97.2的总检测AUROC，优于所有以前的方法，这些方法在不使用其他数据集的情况下学习。可在https://github.com/hmsch/natural-synthetic-anomalies上获得代码。

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Recent work in large language modeling (LLMs) has used fine-tuning to align outputs with the preferences of a prototypical user. This work assumes that human preferences are static and homogeneous across individuals, so that aligning to a a single "generic" user will confer more general alignment. Here, we embrace the heterogeneity of human preferences to consider a different challenge: how might a machine help people with diverse views find agreement? We fine-tune a 70 billion parameter LLM to generate statements that maximize the expected approval for a group of people with potentially diverse opinions. Human participants provide written opinions on thousands of questions touching on moral and political issues (e.g., "should we raise taxes on the rich?"), and rate the LLM's generated candidate consensus statements for agreement and quality. A reward model is then trained to predict individual preferences, enabling it to quantify and rank consensus statements in terms of their appeal to the overall group, defined according to different aggregation (social welfare) functions. The model produces consensus statements that are preferred by human users over those from prompted LLMs (>70%) and significantly outperforms a tight fine-tuned baseline that lacks the final ranking step. Further, our best model's consensus statements are preferred over the best human-generated opinions (>65%). We find that when we silently constructed consensus statements from only a subset of group members, those who were excluded were more likely to dissent, revealing the sensitivity of the consensus to individual contributions. These results highlight the potential to use LLMs to help groups of humans align their values with one another.

通过移动机器人收集数据的自动化有望提高环境调查的功效，但要求该系统自主确定如何在避免障碍的同时采样环境。现有的方法，例如Boustrophedon分解算法，可以将环境完全覆盖到指定的分辨率上，但是在许多情况下，分布分辨率进行采样将产生长的路径，并具有不可算数的测量值。减少这些路径可能会导致可行的计划，而以分配估计精度为代价。这项工作探讨了分布精度和小路分解算法的路径长度之间的权衡。我们通过计算指标来量化算法性能，以在环境分布中计算蒙特卡洛模拟中的准确性和路径长度。我们强调的是，应将一个目标优先于另一个目标，并提出对算法的修改，以通过更均匀地采样来提高其有效性。这些结果证明了Boustrophedon算法的智能部署如何有效指导自主环境抽样。

语言模型既展示了定量的改进，又展示了新的定性功能，随着规模的增加。尽管它们具有潜在的变革性影响，但这些新能力的特征却很差。为了为未来的研究提供信息，为破坏性的新模型能力做准备，并改善社会有害的效果，至关重要的是，我们必须了解目前和近乎未来的能力和语言模型的局限性。为了应对这一挑战，我们介绍了超越模仿游戏基准（Big Bench）。 Big Bench目前由204个任务组成，由132家机构的442位作者贡献。任务主题是多样的，从语言学，儿童发展，数学，常识性推理，生物学，物理学，社会偏见，软件开发等等。 Big-Bench专注于被认为超出当前语言模型的功能的任务。我们评估了OpenAI的GPT型号，Google内部密集变压器体系结构和大型基础上的开关稀疏变压器的行为，跨越了数百万到数十亿个参数。此外，一个人类专家评估者团队执行了所有任务，以提供强大的基准。研究结果包括：模型性能和校准都随规模改善，但绝对的术语（以及与评估者的性能相比）；在模型类中的性能非常相似，尽管带有稀疏性。逐渐和预测的任务通常涉及大量知识或记忆成分，而在临界规模上表现出“突破性”行为的任务通常涉及多个步骤或组成部分或脆性指标；社交偏见通常会随着含糊不清的环境而随着规模而增加，但这可以通过提示来改善。

为了开发直肠癌的自动化工作流程，三维形成式放射治疗计划，结合了深度学习（DL）孔径预测和前向规划算法。我们设计了一种算法来自动化临床工作流程，以使用现场场地进行计划。对555名患者进行了训练，验证和测试DL模型，以自动生成一级和增强场的光圈形状。网络输入是数字重建的X射线照相，总肿瘤体积（GTV）和Nodal GTV。一名医师以5分制（> 3个可以接受）为20名患者的每个孔径为每个孔径评分。然后开发了一种计划算法，以使用楔形和子场的组合创建均匀剂量。该算法迭代识别热点卷，创建子字段并在没有用户干预的情况下优化光束重量。使用具有不同设置的临床光圈对20例患者进行了测试，并由医生评分结果计划（4例计划/患者）。端到端的工作流程通过医生对39名使用DL生成的孔径和计划算法进行了测试和评分。预测的孔的骰子得分分别为0.95、0.94和0.90，分别为侧面，外侧和升压场。 100％，95％和87.5％的后侧，外侧和升压孔分别为临床上可接受。在85％和50％的患者中，楔形计划和非界定计划在临床上是可以接受的。最终计划的热点剂量百分比从121％（$ \ $ 14％）降低到处方剂量的109％（$ \ pm $ 5％）。自动生成的光圈和优化现场计划的综合端到端工作流程为38/39（97％）的患者提供了可接受的计划。我们已经成功地自动化了临床工作流程，以为我们的机构生成放射疗法计划。

小规模过程的建模是气候模型中的主要误差来源，阻碍了低成本模型的准确性，必须通过参数化近似此类过程。红噪声对于许多操作参数化方案至关重要，有助于建模时间相关性。我们通过将随机性的已知好处与机器学习相结合，展示了如何基于红噪声的成功。这是在概率框架内使用物理信息的复发性神经网络完成的。当应用于Lorenz 96大气模拟时，我们的模型具有竞争力，通常优于定制基线和现有的概率机器学习方法（GAN）。这是由于其与标准一阶自回旋方案相比，它具有较高的时间模式的能力。这也是看不见的场景。我们评估了文献中的许多指标，还讨论了使用持有可能性的概率度量的好处。

The recent increase in public and academic interest in preserving biodiversity has led to the growth of the field of conservation technology. This field involves designing and constructing tools that utilize technology to aid in the conservation of wildlife. In this article, we will use case studies to demonstrate the importance of designing conservation tools with human-wildlife interaction in mind and provide a framework for creating successful tools. These case studies include a range of complexities, from simple cat collars to machine learning and game theory methodologies. Our goal is to introduce and inform current and future researchers in the field of conservation technology and provide references for educating the next generation of conservation technologists. Conservation technology not only has the potential to benefit biodiversity but also has broader impacts on fields such as sustainability and environmental protection. By using innovative technologies to address conservation challenges, we can find more effective and efficient solutions to protect and preserve our planet's resources.

We present the interpretable meta neural ordinary differential equation (iMODE) method to rapidly learn generalizable (i.e., not parameter-specific) dynamics from trajectories of multiple dynamical systems that vary in their physical parameters. The iMODE method learns meta-knowledge, the functional variations of the force field of dynamical system instances without knowing the physical parameters, by adopting a bi-level optimization framework: an outer level capturing the common force field form among studied dynamical system instances and an inner level adapting to individual system instances. A priori physical knowledge can be conveniently embedded in the neural network architecture as inductive bias, such as conservative force field and Euclidean symmetry. With the learned meta-knowledge, iMODE can model an unseen system within seconds, and inversely reveal knowledge on the physical parameters of a system, or as a Neural Gauge to "measure" the physical parameters of an unseen system with observed trajectories. We test the validity of the iMODE method on bistable, double pendulum, Van der Pol, Slinky, and reaction-diffusion systems.

While the brain connectivity network can inform the understanding and diagnosis of developmental dyslexia, its cause-effect relationships have not yet enough been examined. Employing electroencephalography signals and band-limited white noise stimulus at 4.8 Hz (prosodic-syllabic frequency), we measure the phase Granger causalities among channels to identify differences between dyslexic learners and controls, thereby proposing a method to calculate directional connectivity. As causal relationships run in both directions, we explore three scenarios, namely channels' activity as sources, as sinks, and in total. Our proposed method can be used for both classification and exploratory analysis. In all scenarios, we find confirmation of the established right-lateralized Theta sampling network anomaly, in line with the temporal sampling framework's assumption of oscillatory differences in the Theta and Gamma bands. Further, we show that this anomaly primarily occurs in the causal relationships of channels acting as sinks, where it is significantly more pronounced than when only total activity is observed. In the sink scenario, our classifier obtains 0.84 and 0.88 accuracy and 0.87 and 0.93 AUC for the Theta and Gamma bands, respectively.